Accelerating Collaboration. Advancing Treatments. Improving Outcomes.
Explore the C3PT Blueprint comprising a multi-stakeholder Position Narrative, and practical implementation tools designed to strengthen academic-industry collaboration in pediatric oncology platform trials. Together, these resources provide a roadmap for overcoming barriers, streamlining partnerships, and accelerating the development of innovative therapies for children and young people with cancer.
Read more in the C3PT Executive Summary >
C3PT Resources/Deliverables
We recommend you start by reading the C3PT Position Narrative Document (PDF) before accessing the C3PT Tools. Use the clickable graphic below to understand the relationship of the tools to the project’s larger themes. You can either open tools for download straight from the clickable graphic OR you can use the buttons available in the sections below.
The C3PT Blueprint
You can click on the labels below to open each tool in a new tab
OR use the buttons in the section below.
C3PT Tools
Platform Trial Decision Tree
This tool lays out a series of scenario-based questions as a stepwise decision framework for determining whether an academic industry collaborative platform trial is the appropriate approach for your trial. It considers factors such as inclusion of multiple therapies, rare populations, feasibility across sites, stakeholder acceptance, industry engagement, patient advocacy, governance capacity and operational infrastructure needs.
Best Practices for Regulatory Interactions Tool
Both the FDA and EMA support a collaborative approach amongst all involved key stakeholders to ensure timely pediatric oncology drug development. This tool lays out the types of regulatory interactions available for multi-stakeholder groups with EMA and FDA.
PIPs and iPSPs Guidance for Collaborative Contributions to Writing Tool
This tool provides guidance on areas within PIPs and iPSPs where the disease-specific and/or target-specific scientific and clinical expertise of the Academic Platform Trial Clinical Leadership can contribute. It helps industry partners identify sections where collaborative input can enhance the quality, accuracy, and scientific robustness of these documents.
Operational Considerations for Academic-Industry Collaborative Platform Trials in Paediatric Oncology
The design and conduct of an academic-industry collaborative trial is a complex and resource intensive undertaking, requiring diverse skills and facilities. This tool is a checklist that includes the principal operational considerations and expertise needed to successfully sponsor and deliver this type of trial and highlights at the onset where the distribution of responsibilities needs to be agreed between academic and industry partners.
Evidence-Based Consolidated Independent Expert Opinion (EBCO) for Academic-Industry Collaborative Platform Trials in Paediatric Oncology
The established frameworks for Academic Platform Trials represent a unique opportunity for industry partners to gain independent authoritative expert advice on paediatric development plans for their assets. Evidence-Based Consolidated Independent Expert Opinions (EBCO) provide a structured approach to informing asset prioritisation decisions for platform trial inclusion. This tool provides guidance to academic sponsors on the potential multi-stakeholder composition and terms of reference for an EBCO Panel.
Glo-BNHL Industry Information Pack
This in a working example from the Glo-BNHL trial of the guidance that an academic sponsor should give to Industry about submitting their asset information to an Evidence-Based Consolidated Independent Expert Opinion Panel. The Glo-BNHL trial, sponsored by the University of Birmingham and managed by the Birmingham Cancer Research UK Clinical Trials Unit (CRCTU), is an international, academic-led, early-phase clinical platform trial designed to efficiently assess multiple prioritized novel agents in paediatric patients with relapsed and refractory BNHL. The document is shared as an example that trialists can adapt for the specific scenario in their industry-academic collaborative trial.
Glo-BNHL Industry Information Pack: Asset Submission Form
This example of an Asset Submission Form related to the Glo-BNHL Industry Information Pack. It includes guidance on the key information required by a platform trial’s Evidence-Based Consolidated Independent Expert Opinion Panel to review an asset for the platform trial. The document is shared as an example that trialists can adapt for the specific scenario in their industry-academic collaborative trial.
Likely Pharma–Academic Pain Points and Practical Solutions
The most problematic clauses in contracts between academic sponsors and industry partners relate to data ownership, intellectual property, publication rights and trial governance that can lead to protracted contract negotiations where the perspective of industry representatives and academic trialists may differ. This tool helps parties navigate these common contractual barriers by offering practical solutions and discussion frameworks that support smoother negotiations, leading to more timely contract execution.
Intellectual Property and Data Sharing Contract Principles for Platform Trials
This document complements Pain Point and Practical Solutions Tool, detailing the shared principles on intellectual property and data sharing for academic-industry collaborative platform trials
Value Proposition of a Platform Trial to Industry Partners
This Tool is focused on optimising the communication of the value proposition of an academic-industry collaborative platform trial to potential industry partners. This short slide deck highlights the platform’s operational efficiencies, regulatory alignments, the established track records of successful prior global collaborations, and importantly, the patient benefit. The slide deck can be readily adapted and personalized to the academic sponsor’s platform trial.
Related Events & Resources
Related Webinar(s):
C3PT Toolkit Launch Webinar | September 22, 2026 @ 10:00 am – 11:00 am
Related Podcasts:
Related Projects & Resources: