Clinical Research Glossary

comparator comparator

CDISC

Something that is compared to the study treatment.

Example of comparator in a sentence

Studies with a comparator are usually trying to find out if there is a different outcome in the comparator group versus the group that gets the study treatment.

More Info

A comparator is also called a “control.” The group that gets the comparator is the “control group.”

The comparator can be an investigational or approved medicine, a placebo, or a different procedure or intervention.

For example, in a study of acupuncture for back pain, a comparator might be physical therapy or yoga.

Other info to think about when joining a study

You may see the word “comparator” to describe another arm in the study. A comparator is often a treatment or intervention in common use and is used to see if the study treatment is worse, better, or somehow different. Feel free to ask any questions you might have about the comparator that is being used in a study.

Version 2.0 September 2024

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