QUALITY AND TRANSPARENCY
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Disclosure of Possible Trial Termination to Participants of Interventional Clinical Trials

Publication

Published on: April 4, 2023

Published in: JAMA

Trial termination (the decision to end a trial earlier than planned) has been reported in 17.9% of cardiovascular trials and 16.0% of surgical trials.1,2 Although some trials are terminated for scientific reasons due to safety, efficacy, or futility, many trials are terminated due to inadequate participant enrollment or other nonscientific reasons.